HTAP: N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease.
Article classé dans la catégorie "HTAP".
Complication que l'on peut rencontrer dans la maladie de Gaucher.
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N-brain natriuretic peptide: correlation with tricuspid insufficiency in Gaucher disease.
Pulm Pharmacol Ther. 2004;17(5):319-23.
Elstein D, Nir A, Klutstein M, Abrahamov A, Zimran A.
Gaucher Clinic, Shaare Zedek Medical Center PO Box Jerusalem , Israel
NT-pro-brain natriuretic peptide (NT-proBNP) values are correlated with right ventricle dysfunction in pulmonary hypertension and have been recommended as a prognostic marker for symptomatic primary pulmonary hypertension. The purpose of this pilot study was to determine whether NT-proBNP values correlate with mild to moderate pulmonary hypertension in Gaucher disease. The NT-proBNP assay was performed on sera from patients with type I (non-neuronopathic) Gaucher disease who were known to have tricuspid insufficiency (TI) gradient values on echocardiography that were normal (TI<20 mmHg), borderline (TI=25-29 mmHg), or abnormal (TI>or= 30 mmHg) over time. There was a statistically significant correlation (p=0.05) between mean NT-proBNP values and TI gradient group: mean NT-proBNP for normal TI gradient (n=20 patients)=133.3 (range: 46-445)pg/ml; mean NT-proBNP for borderline TI gradient (n=17 patients)=288.7 (range: 81-1088)pg/ml; and mean NT-proBNP for elevated TI gradient (n=10 patients)=1034.2 (73-6703)pg/ml. Treatment status was not correlated with TI gradient or NT-proBNP values. Thus, in this pilot study of Gaucher disease that included patients with mild to moderate pulmonary hypertension, NT-proBNP was correlated with echocardiographic findings. Further studies will be required to ascertain if NT-proBNP can be used for diagnosis and monitoring of these patients.
PMID: 15477128 [PubMed - indexed for MEDLINE]